Not known Factual Statements About phenobarbital sodium drug class
Not known Factual Statements About phenobarbital sodium drug class
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pentobarbital will minimize the level or effect of lefamulin by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Prevent coadministration of lefamulin with strong or moderate CYP3A inducers Until the profit outweighs threats. Watch for reduced efficacy.
pentobarbital will lessen the extent or effect of zolpidem by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Importance Unidentified.
buprenorphine subdermal implant and pentobarbital equally improve sedation. Steer clear of or Use Alternate Drug. Limit use to clients for whom alternative therapy options are inadequate
pentobarbital will reduce the extent or effect of ombitasvir/paritaprevir/ritonavir & dasabuvir (DSC) by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Powerful CYP3A4 inducers may possibly cut down partiaprevir and ritonavir degrees, and for that reason reduced efficacy of Viekira Pak
pentobarbital raises toxicity of buprenorphine, lengthy-performing injection by pharmacodynamic synergism. Modify Therapy/Keep track of Intently. Coadministration of buprenorphine and benzodiazepines or other CNS depressants raises danger of adverse reactions including overdose, respiratory despair, and Loss of life. Cessation of benzodiazepines or other CNS depressants is chosen generally.
pentobarbital will reduce the extent or effect of armodafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Importance Unidentified.
pentobarbital will decrease the level or effect of quetiapine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
pentobarbital will decrease the extent or effect of parecoxib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Importance Mysterious.
Doxycycline: Phenobarbital has long been demonstrated to shorten the half-life of doxycycline for so long as 2 weeks following barbiturate therapy is discontinued.
Corticosteroids: Barbiturates surface to reinforce the metabolism of exogenous corticosteroids possibly throughout the induction of hepatic microsomal enzymes. Patients stabilized on corticosteroid therapy may perhaps have to have dosage adjustments if barbiturates are included to or withdrawn from their dosage regimen.
pentobarbital will lessen the extent or effect of piroxicam by affecting hepatic enzyme CYP2C9/ten metabolism. Small/Significance Mysterious.
The effect from the resultant decreased blood amounts of griseofulvin on therapeutic reaction has not been established. However, It will be preferable to stop concomitant administration of those drugs.
pentobarbital will lessen the extent or effect of acalabrutinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.
Knowledge in rodents As well as in primates counsel read more that the neuronal and oligodendrocyte mobile losses are affiliated with refined but extended cognitive deficits in Discovering and memory. The scientific importance of such nonclinical conclusions is not known, and Health care providers should really balance the main advantages of acceptable anesthesia in neonates and youthful kids who involve strategies against the possible risks advised through the nonclinical information (see “Warnings-Pediatric Neurotoxicity” and “Precautions-Pregnancy and Pediatric Use”). AKORN